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A double-blind evaluation of oral indoprofen versus ASA in osteoarthritic patients: influence on haemostatic parameters and clinical effects.
- Source :
-
European journal of rheumatology and inflammation [Eur J Rheumatol Inflamm] 1981; Vol. 4 (1), pp. 41-8. - Publication Year :
- 1981
-
Abstract
- Indoprofen, a non-steroidal anti-inflammatory agent, was investigated in a double-blind, randomized study in 44 osteoarthritic patients for its influence on haemostatic parameters and therapeutic effects. Twenty-two patients received indoprofen orally, 600 mg daily, and a similar group took acetylsalicylic acid 3 g daily for 21 days. Platelet count, partial thromboplastin time and prothrombin time showed no variations. Bleeding time wa prolonged and platelet aggregation reduced by both drugs. The effects of ASA, however, were significantly greater. Indoprofen, unlike ASA, showed almost no residual effect seven days after stopping medication. The therapeutic responses to indoprofen and ASA were comparable. However, adverse reactions (pyrosis and gastric pain) were much more frequent in the ASA group (15 patients) than in the indoprofen group (2 patients).
- Subjects :
- Adult
Aged
Aspirin adverse effects
Bleeding Time
Clinical Trials as Topic
Double-Blind Method
Female
Heartburn chemically induced
Humans
Male
Middle Aged
Osteoarthritis blood
Pain chemically induced
Prothrombin Time
Stomach
Aspirin therapeutic use
Hemostasis drug effects
Indoprofen therapeutic use
Osteoarthritis drug therapy
Phenylpropionates therapeutic use
Platelet Aggregation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0140-1610
- Volume :
- 4
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of rheumatology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 7042361