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Role of the acute phase response in the Shwartzman phenomenon.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 1982 Feb; Vol. 47 (2), pp. 289-95. - Publication Year :
- 1982
-
Abstract
- Following elicitation of the local Shwartzman reaction by intradermal injection of Salmonella enteritidis lipopolysaccharide (LPS) in mice, there was a marked acute phase response which was monitored by measuring the serum levels of serum amyloid P component (SAP) and C3. Prednisolone therapy had no effect on either the cutaneous lesion or the accompanying acute phase response. Also, in vivo complement depletion with cobra factor did not affect the lesion or the SAP response despite gross reduction in serum C3 levels. In contrast, administration of colchicine at the same time as LPS suppressed both the acute phase response and the Shwartzman reaction. Inhibition of the cutaneous reaction by colchicine was abrogated by injecting mice with casein, and unrelated acute phase stimulus, the day before challenge with LPS. These observations suggest that acute phase proteins may participate in pathogenesis of the Shwartzman phenomenon.
- Subjects :
- Amyloid blood
Animals
Colchicine therapeutic use
Complement C3 analysis
Lipopolysaccharides immunology
Mice
Mice, Inbred C57BL
Prednisolone therapeutic use
Salmonella enteritidis immunology
Serum Amyloid P-Component
Shwartzman Phenomenon pathology
Shwartzman Phenomenon prevention & control
Skin pathology
Shwartzman Phenomenon immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9104
- Volume :
- 47
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 7042139