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Fansidar resistant falciparum malaria acquired in South East Asia.
- Source :
-
Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 1981; Vol. 75 (5), pp. 715-6. - Publication Year :
- 1981
-
Abstract
- A case of Plasmodium falciparum malaria resistant to Fansidar (sulphadoxine plus pyrimethamine) at a level corresponding to R III and resistant to chloroquine is reported. The infection was most certainly acquired in Malaysia, but diagnosed and treated in a non-malarious area. Normal resorption and elimination rates of the Fansidar components excludes cure failure due to abnormal drug fate in the host. P. falciparum parasites from the patient have been maintained in vitro cultures. The patient was permanently cured with mefloquine.
- Subjects :
- Adult
Antimalarials metabolism
Antimalarials therapeutic use
Drug Combinations metabolism
Drug Combinations therapeutic use
Drug Resistance, Microbial
Female
Humans
Malaysia
Plasmodium falciparum
Pyrimethamine metabolism
Sulfadoxine metabolism
Malaria drug therapy
Pyrimethamine therapeutic use
Sulfadoxine therapeutic use
Sulfanilamides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0035-9203
- Volume :
- 75
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 7036431
- Full Text :
- https://doi.org/10.1016/0035-9203(81)90160-7