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Quantitative selected ion monitoring (QSIM) of drugs and/or drug metabolites in biological matrices.
- Source :
-
Journal of chromatographic science [J Chromatogr Sci] 1981 Aug; Vol. 19 (8), pp. 392-434. - Publication Year :
- 1981
-
Abstract
- From a modest beginning, QSIM has established itself with over three hundred applications in the 1970s as not only a reference technique for other methods but also as a useful method in its own right for the quantitation of drugs in biological matrices. Relative to its potential sensitivity, the actual sensitivity of QSIM drug assays is disappointing, although a number of QSIM drug assays report LOQs of 250 pg ml-1 or less. The mean reported precision of QSIM drug assays (approximately 6%) is similar to that of traditional GC and LC assays, but is an order of magnitude less than either what is theoretically possible or what has been demonstrated in a few selected QSIM assays.
Details
- Language :
- English
- ISSN :
- 0021-9665
- Volume :
- 19
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of chromatographic science
- Publication Type :
- Academic Journal
- Accession number :
- 7024291
- Full Text :
- https://doi.org/10.1093/chromsci/19.8.392