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Treatment of rheumatoid arthritis with flurbiprofen: a comparison with enteric-coated aspirin.
- Source :
-
Current medical research and opinion [Curr Med Res Opin] 1981; Vol. 7 (7), pp. 418-22. - Publication Year :
- 1981
-
Abstract
- Forty patients with definite or classical rheumatoid arthritis were entered for 3 months in a double-blind trial, 20 patients each on 200 mg flurbiprofen or 4.0 g enteric-coated aspirin daily. Statistically significant improvements (Page Test, p less than 0.05) on flurbiprofen were reported during the course of the study for 7 out of 20 parameters: degree of pain, duration of morning stiffness, grip strength, torquometer, Ritchie articular index, number of swollen joints and patient's overall assessment, while for aspirin a significant improvement was reported for 5 parameters: degree of pain, PIP joint size, Ritchie articular index and physician's overall assessment. The amount of improvement between flurbiprofen and enteric-coated aspirin differed significantly (Kruskal-Wallis H Test) only for 2 parameters: Ritchie articular index and number of swollen joints. In both cases the degree of improvement was greater on flurbiprofen than an aspirin. Side-effects were reported for 7 patients receiving aspirin (2 of which were severe enough that treatment had to be stopped) and for 3 patients receiving flurbiprofen. Except for 2 cases of tinnitus on aspirin, the side-effects were mostly gastro-intestinal in nature. A significant decrease was found for patients receiving aspirin. A significant increase in blood urea occurred on flurbiprofen. Most values, however, remained within normal limits. The results suggests that flurbiprofen is better tolerated and at least as effective as enteric-coated aspirin in the treatment of patients with rheumatoid arthritis.
- Subjects :
- Adult
Aged
Aspirin adverse effects
Clinical Trials as Topic
Double-Blind Method
Female
Flurbiprofen adverse effects
Humans
Male
Middle Aged
Random Allocation
Tablets, Enteric-Coated
Arthritis, Rheumatoid drug therapy
Aspirin therapeutic use
Flurbiprofen therapeutic use
Propionates therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0300-7995
- Volume :
- 7
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Current medical research and opinion
- Publication Type :
- Academic Journal
- Accession number :
- 7021070
- Full Text :
- https://doi.org/10.1185/03007998109114278