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Immunoglobulin-bearing lymphoid cells in primary syphilis. Quantitative and elution studies.
- Source :
-
The British journal of venereal diseases [Br J Vener Dis] 1980 Apr; Vol. 56 (2), pp. 69-73. - Publication Year :
- 1980
-
Abstract
- The delay in antibody production in response to infection with Treponema pallidum may be caused by a block in the differentiation of antigen-stimulated B (Bursa-dependent) lymphoid cells towards plasma cells. This hypothesis was tested by a study to detect clonal expansion of immunoglobulin-bearing B lymphoid cells by in-vitro immunofluorescence tests in patients with primary syphilis. In addition, antibodies eluted from circulating lymphoid cells were investigated for treponemal binding by the enzyme-linked immunosorbent assay, the T pallidum immobilisation test, and the immunoglobulin class-specific FTA-ABS test. Results indicated that the number of IgG-bearing lymphoid cells were increased in patients with primary syphilis. However, in only a few cases could antitreponemal antibodies be eluted from isolated lymphoid cells. For this reason, the original hypothesis was rejected.
Details
- Language :
- English
- ISSN :
- 0007-134X
- Volume :
- 56
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The British journal of venereal diseases
- Publication Type :
- Academic Journal
- Accession number :
- 6992939
- Full Text :
- https://doi.org/10.1136/sti.56.2.69