Back to Search
Start Over
Immunologic effects of whole-body ultraviolet irradiation: selective defect in splenic adherent cell function in vitro.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1980 May; Vol. 77 (5), pp. 2881-5. - Publication Year :
- 1980
-
Abstract
- Splenocytes from mice receiving whole-body UV irradiation do not make a normal primary in vitro plaque-forming cell (PFC) response to the soluble T-dependent antigen trinitrophenylated poly(L-glutamic acid60L-alanine30L-tyrosine10). This impaired immune response results from a selective loss of antigen-presenting cell function in the splenic adherent cell (SAC) population of the UV-treated mice. SACs from UV-irradiated mice are unable to reconstitute a PFC response when added to normal splenocytes passed through Sephadex G-10 (which depletes adherent cells), whereas normal SACs, when added to Sephadex G-10-passed splenocytes from UV-treated mice, do restore a PFC response. The effect of in vivo UV irradiation on the SAC population is indistinguishable functionally from the effect of in vitro UV irradiation of SACs from normal mice. Possible explanations for this selective effect of external UV irradiation on SAC function are discussed.
- Subjects :
- Animals
Cell Adhesion
Cells, Cultured
Female
Immunoglobulin M biosynthesis
Lymphocyte Cooperation radiation effects
Male
Mice
Peptides immunology
Receptors, Antigen, T-Cell analysis
Spleen immunology
Antibody Formation radiation effects
Spleen radiation effects
T-Lymphocytes immunology
Ultraviolet Rays
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 77
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 6967214
- Full Text :
- https://doi.org/10.1073/pnas.77.5.2881