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Treatment of prolymphocytic leukemia.
- Source :
-
Cancer [Cancer] 1982 Nov 01; Vol. 50 (9), pp. 1687-9. - Publication Year :
- 1982
-
Abstract
- Prolymphocytic leukemia is characterized by marked splenomegaly, distinctive cellular morphologic characteristics, and a poor clinical course. Five patients with typical PL were treated systematically with vincristine/prednisone, chlorambucil/prednisone, splenic irradiation, splenectomy, and other chemotherapy regimens. No patient responded to vincristine/prednisone. Two patients responded to chlorambucil/prednisone, and four patients had brief responses to splenic irradiation. Two patients underwent splenectomy, one of whom had a prolonged clinical remission. There were no complete remissions. No other chemotherapy combinations were of value. The median survival was 33 months. Recommendations are made to use chlorambucil/prednisone or splenic irradiation as initial treatment. Splenectomy should be considered in patients refractory to these modalities. The course of PL may be more protracted than originally reported.
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 50
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 6956431
- Full Text :
- https://doi.org/10.1002/1097-0142(19821101)50:9<1687::aid-cncr2820500905>3.0.co;2-i