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Plasmid-mediated antibiotic resistance in methicillin-resistant Staphylococcus aureus.
- Source :
-
The Medical journal of Australia [Med J Aust] 1982 May 29; Vol. 1 (11), pp. 468-9. - Publication Year :
- 1982
-
Abstract
- Strains of methicillin-resistant Staphylococcus aureus (MRSA), isolated from clinical sources in Victoria, were screened for the presence of plasmid DNA. Resistance to gentamicin, kanamycin, and tobramycin was found to reside on an 18-megadalton plasmid, and resistance to chloramphenicol was mediated by a 3-megadalton plasmid. No extra-chromosomal locus was found for resistance to several other antibiotics, including methicillin. Local strains of MRSA differ from their international counterparts by the possession of extensive chromosomal resistance determinants. Together with those encoded on plasmids, these determinants are capable of neutralising almost all available antistaphylococcal antibiotics.
- Subjects :
- Australia
Cross Infection microbiology
DNA, Bacterial analysis
Electrophoresis, Agar Gel
Gentamicins pharmacology
Humans
Kanamycin pharmacology
Staphylococcal Infections microbiology
Staphylococcus aureus classification
Tobramycin pharmacology
Methicillin pharmacology
Penicillin Resistance
Plasmids drug effects
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0025-729X
- Volume :
- 1
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Medical journal of Australia
- Publication Type :
- Academic Journal
- Accession number :
- 6920562
- Full Text :
- https://doi.org/10.5694/j.1326-5377.1982.tb132418.x