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Adrenocortical hemorrhagic necrosis: the role of catecholamines and retrograde medullary-cell embolism.
- Source :
-
Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 1981 Oct; Vol. 105 (10), pp. 536-9. - Publication Year :
- 1981
-
Abstract
- We investigated the pathogenesis of adrenal necrosis using animal models of the disease (induced by administration of acrylonitrile, cysteamine, or pyrazole) and human cases. Results of electron-microscopic and histochemical time-response studies with rat models revealed an early, retrograde embolization of medullary cells and cell fragments in the cortical capillaries that showed prominent endothelial injury. The experimental adrenal lesions were prevented by surgical removal of the medulla one month before administration of adrenocorticolytic chemicals, or by the administration of the alpha-adrenergic antagonist phenoxybenzamine hydrochloride. Histochemical staining for medullary (argyrophil) granules in human cases of adrenal necrosis demonstrated tissue fragments that stained positively for silver in vascular cortical spaces in nine of ten autopsy specimens and in all four surgical cases we reviewed. Thus, catecholamines released from the adrenal medulla and from the retrograde medullary emboli in the cortex may have a role in the pathogenesis of adrenocortical necrosis.
- Subjects :
- Acrylonitrile pharmacology
Adrenal Cortex Diseases etiology
Adrenal Medulla physiology
Animals
Cysteamine pharmacology
Disease Models, Animal
Embolism complications
Female
Hemorrhage etiology
Humans
Necrosis
Pyrazoles pharmacology
Rats
Rats, Inbred Strains
Adrenal Cortex Diseases pathology
Adrenal Medulla pathology
Catecholamines physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9985
- Volume :
- 105
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Archives of pathology & laboratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6895166