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Malignant histiocytosis. Clinical and cytogenetic studies in a newborn and a child.
- Source :
-
Cancer [Cancer] 1983 Oct 01; Vol. 52 (7), pp. 1229-36. - Publication Year :
- 1983
-
Abstract
- Malignant histiocytosis (MH) was diagnosed on the cytologic and cytochemical features of the malignant cells present in bone marrow smears from an infant and a child. The diagnosis of MH was confirmed by light and electron microscopic studies on bone marrow and skin biopsy specimens, and bone marrow and liver biopsy specimens, respectively. Both patients showed a deterioration while receiving prednisone monotherapy, but they responded well to a combination of vincristine and cyclophosphamide. The infant has remained disease-free for 52+ months now, but the child died of a relapse 11 months after diagnosis. Cytogenetic studies of blood and/or bone marrow cells were performed before treatment. In the infant, a pathologic cell line with a translocation t(8;16)(p11;p13) was found; this abnormality was no longer present after remission was obtained. In the second patient, a hyperdiploid cell line with major karyotypic anomalies was found. When studied in relapse and shortly before death, additional chromosomal abnormalities were seen. The data from this study show that prednisone should be used with caution in MH, and that it should be omitted from combination chemotherapy when adverse effects are noted during short-term monotherapy. Also, cytogenetic studies should be performed more often in MH to determine the significance and possible nonrandomness of chromosomal abnormalities in this disease.
- Subjects :
- Antineoplastic Agents therapeutic use
Bone Marrow pathology
Child, Preschool
Chromatin ultrastructure
Chromosome Aberrations
Chromosome Disorders
Humans
Infant, Newborn
Karyotyping
Lymphatic Diseases drug therapy
Lymphatic Diseases genetics
Male
Microscopy, Electron
Translocation, Genetic
Lymphatic Diseases pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 52
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 6883287
- Full Text :
- https://doi.org/10.1002/1097-0142(19831001)52:7<1229::aid-cncr2820520717>3.0.co;2-n