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Lethal and cytokinetic effects of anguidine on a human colon cancer cell line.
- Source :
-
Cancer research [Cancer Res] 1978 Oct; Vol. 38 (10), pp. 3304-9. - Publication Year :
- 1978
-
Abstract
- Anguidine is a fungal metabolite with antitumor activity in a murine colon cancer model. Because of disappointing results in clinical trials, we analyzed the lethal and cytokinetic effects of anguidine on cultured human colon cancer cells. The studies revealed a moderate reduction in survival only after prolonged drug exposure. Continuous incubation with anguidine for longer than 48 hr produced a moderate increase in the percentage of S-phase cells and a slight decrease in the proportion of cells in G1/0, by pulse cytophotometry. An immediate reduction in the cumulative labeling index for cells continuously exposed to tritiated thymidine and anguidine and a rapid decrease in the cumulative mitotic index for cells continuously exposed to Colcemid and anguidine indicated a block at the G1 into S and G2 into mitosis transitions. Tumoricidal activity of anguidine in a cultured human colon cancer line is poor and requires prolonged exposure. The kinetic data reflect an almost frozen state of the cell cycle.
- Subjects :
- Adenocarcinoma pathology
Cell Cycle drug effects
Cell Line
Cell Survival drug effects
Colonic Neoplasms pathology
Humans
Kinetics
Neoplasms, Experimental drug therapy
Trichothecenes administration & dosage
Adenocarcinoma drug therapy
Colonic Neoplasms drug therapy
Sesquiterpenes pharmacology
Trichothecenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 38
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 688220