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Haemodynamic and metabolic effects of timolol (Blocadren) on ischaemic myocardium.

Haemodynamic and metabolic effects of timolol (Blocadren) on ischaemic myocardium.

Authors :
Simonsen S
Ihlen H
Kjekshus JK
Source :
Acta medica Scandinavica [Acta Med Scand] 1983; Vol. 213 (5), pp. 393-8.
Publication Year :
1983

Abstract

The effects of timolol (2.5 mg i.v.) on coronary haemodynamics and myocardial metabolism were studied in 26 patients with angina pectoris. Cardiac venous flow (CVF) was measured by thermodilution technique. Blood was sampled for metabolic studies. Angina pectoris was induced by atrial pacing and the same heart rate was regained after timolol. Metabolic ischaemia was defined as reduction in myocardial lactate extraction ratio (MLE) by at least 50% and to a ratio below 0.15. The study was completed in 22 patients, 9 of whom fulfilled the metabolic criteria for ischaemia. This subgroup did not differ from the total group in any other respect than in lactate metabolism. Beta-adrenergic blockade reduced myocardial oxygen consumption (MVO2) and CVF significantly at rest, but MVO2, CVF, myocardial glucose uptake and MLE were unchanged during pacing despite a decrease in systolic aortic pressure, ejection time and reduced myocardial free fatty acid uptake. Conclusively, timolol did not reduce MVO2 and metabolic ischaemia during pacing-induced angina.

Details

Language :
English
ISSN :
0001-6101
Volume :
213
Issue :
5
Database :
MEDLINE
Journal :
Acta medica Scandinavica
Publication Type :
Academic Journal
Accession number :
6880861
Full Text :
https://doi.org/10.1111/j.0954-6820.1983.tb03757.x