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Advantage of hand bone calcium content measurement by local neutron activation analysis for following up hemodialysis patients.
- Source :
-
Nephron [Nephron] 1983; Vol. 34 (4), pp. 228-33. - Publication Year :
- 1983
-
Abstract
- Hand bone calcium content [Ca] has been measured by local neutron analysis in hemodialyzed patients free of signs of osteomalacia before and 6-12 months after treatment with vitamin D metabolites, and it has been compared to some iliac bone histomorphometric parameters. With 1,25-(OH)2D3 alone, [Ca] increases significantly at the 6th month of treatment (p less than 0.001) but not from the 6th to the 12th month. With 1 alpha-(OH)D3 + 25-(OH)D3 the same phenomenon is observed at the 6th and 12th months of treatment. Before treatment, [Ca] was correlated negatively with the osteoid surfaces (OS) (r = -0.62, p = 0.01) and the number of osteoclasts per square millimeter (Ocl/mm2) (r = -0.79, p less than 0.001). At the 6th month of treatment, [Ca] was still correlated negatively with OS (r = -0.42, p = 0.05) and with Ocl/mm2 (r = -0.60, p less than 0.005). At the 12th month, the two negative correlations decreased but remained significant (r = -0.42, p = 0.05; r = -0.45, p = 0.05). These data suggest that (1) hand bone calcium analysis by neutron activation permits to follow up the peripheral bone mineral content in hemodialyzed patients and (2) the [Ca] increase only observed during the first months of treatment with vitamin D metabolites probably result from an attenuation of secondary hyperparathyroidism.
- Subjects :
- Adult
Aged
Female
Follow-Up Studies
Humans
Hydroxycholecalciferols therapeutic use
Ilium pathology
Kidney Diseases metabolism
Kidney Diseases therapy
Male
Middle Aged
Monitoring, Physiologic methods
Neutron Activation Analysis methods
Osteomalacia prevention & control
Time Factors
Calcium metabolism
Carpal Bones metabolism
Metacarpus metabolism
Renal Dialysis
Subjects
Details
- Language :
- English
- ISSN :
- 1660-8151
- Volume :
- 34
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nephron
- Publication Type :
- Academic Journal
- Accession number :
- 6877458
- Full Text :
- https://doi.org/10.1159/000183021