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The effects of aflatoxin B1 on rat fetal lung lipids.

Authors :
Das SK
Nair RC
Patthey HL
Mgbodile MU
Source :
Biology of the neonate [Biol Neonate] 1978; Vol. 33 (5-6), pp. 283-8.
Publication Year :
1978

Abstract

The administration of aflatoxin B1 to rats on days 17 and 19 of pregnancy caused increased synthesis of the total lipids and the fatty acids, and decreased synthesis of the phosphatidyl choline in 21-day-old fetal lung. Aflatoxin B1 caused toxicity in the fetal lung as evidenced by the excessive accumulation of the lamellar bodies and the osmiophilic spheroids in the type II cells and the alveolar lumen, respectively. The rearrangement of the lamellar form to the continuous sheet-like tubular myelin form was reduced in the alveolar lumen of the treated lung.

Details

Language :
English
ISSN :
0006-3126
Volume :
33
Issue :
5-6
Database :
MEDLINE
Journal :
Biology of the neonate
Publication Type :
Academic Journal
Accession number :
687696
Full Text :
https://doi.org/10.1159/000241085