Back to Search
Start Over
Effect of piracetam in some models of general and local depression of the cortical bioelectrical activity in cats.
- Source :
-
Archives internationales de pharmacodynamie et de therapie [Arch Int Pharmacodyn Ther] 1983 Mar; Vol. 262 (1), pp. 13-23. - Publication Year :
- 1983
-
Abstract
- The effect of piracetam (100 mg/kg i.v.) on general and local depression of the cortical bioelectrical activity was studied in acute experiments on cats. Asphyxic anoxia and hypoventilation hypoxia were used as models of general depression. Local depressions were caused by topical application of potassium chloride (KCl), adenosine monophosphate (AMP) and pentobarbital on the cortex. In the models of general depression piracetam increased cortical resistance to hypoxia and accelerated the recovery of the cortical bioelectrical activity. In KCl- and AMP-induced depressions piracetam diminished their degree and duration and completely protected the cortex against pentobarbital-caused depression.
- Subjects :
- Adenosine Monophosphate pharmacology
Animals
Asphyxia physiopathology
Cats
Cerebral Cortex physiology
Depression, Chemical
Female
Hypoxia physiopathology
Male
Pentobarbital pharmacology
Potassium Chloride pharmacology
Cerebral Cortex drug effects
Piracetam pharmacology
Pyrrolidinones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9780
- Volume :
- 262
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives internationales de pharmacodynamie et de therapie
- Publication Type :
- Academic Journal
- Accession number :
- 6870386