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The changing incidence of association of hepatitis B with hepatocellular carcinoma in California.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 1977 Jul; Vol. 68 (1), pp. 1-7. - Publication Year :
- 1977
-
Abstract
- Two hundred seventy-nine patients who died of hepatocellular carcinoma were autopsied at Los Angeles County--USC Medical Center and the John Wesley--USC Liver Unit from 1949 through 1974, and tissues from 168 of these cases were available for staining for hepatitis B surface antigen (HBSAg). Twenty-one per cent of the livers had stainable HBSAg. There were prominent increases both in total numbers of hepatic cancers and in the percentages that were HBSAg-positive beginning about 1970, but the numbers of hepatocellular carcinomas arising in noncirrhotic livers also increased. From 1969 to 1974, 73% of those who had hepatocellular carcinomas arising to nonalcoholic but cirrhotic livers were HBSAg-positive. Racial differences in the incidences of cirrhosis, the incidences of hepatocellular carcinomas associated with HBSAg were found. The incidences of cirrhosis were: Caucasian 11%; Mexican 12.2%; Negro 5.7:; Oriental 10%. Hepatocellular carcinomas arose in 3.2% of Caucasians who had cirrhosis; 3.6% of Mexicans; 8.3% of Negroes; 47% or Orientals. Ten per cent of Caucasians who had hepatocellular carcinomas in cirrhotic livers were HBSAg-positive; 25% of Negroes; 12% of Mexicans; 47% of Orientals.
- Subjects :
- Adenocarcinoma pathology
Adult
Black People
California
Carcinoma, Hepatocellular epidemiology
Carcinoma, Hepatocellular pathology
Female
Hepatitis B epidemiology
Hepatitis B Surface Antigens
Humans
Liver Cirrhosis complications
Liver Cirrhosis epidemiology
Liver Neoplasms epidemiology
Liver Neoplasms pathology
Mexico ethnology
Staining and Labeling
White People
Black or African American
Carcinoma, Hepatocellular complications
Hepatitis B complications
Liver Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9173
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 68678
- Full Text :
- https://doi.org/10.1093/ajcp/68.1.1