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Impact of dosing intervals on activity of gentamicin and ticarcillin against Pseudomonas aeruginosa in granulocytopenic mice.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1983 May; Vol. 147 (5), pp. 910-7. - Publication Year :
- 1983
-
Abstract
- The influence of dosing intervals on the activity of gentamicin and ticarcillin against Pseudomonas aeruginosa was studied in vivo. Granulocytopenic mice infected with P. aeruginosa in the thigh muscle were treated with 1-hr or 3-hr injections of gentamicin, ticarcillin, or gentamicin-ticarcillin. Plasma pharmacokinetics of the drugs were correlated with antibacterial activity. Gentamicin injected every 1 hr tended to be less active than gentamicin injected at longer intervals. In contrast, ticarcillin given every 1 hr was significantly more efficacious than equivalent total doses injected every 3 hr. The dosing schedule of gentamicin-ticarcillin was again important for ticarcillin but did not appreciably affect the antibacterial activity of gentamicin. Thus, antimicrobial chemotherapy of P. aeruginosa infections in the granulocytopenic host might be improved by administering ticarcillin rather than gentamicin as a constant infusion.
- Subjects :
- Animals
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Female
Gentamicins metabolism
Kinetics
Mice
Mice, Inbred ICR
Pseudomonas Infections complications
Ticarcillin metabolism
Agranulocytosis complications
Gentamicins therapeutic use
Penicillins therapeutic use
Pseudomonas Infections drug therapy
Ticarcillin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 147
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 6842025
- Full Text :
- https://doi.org/10.1093/infdis/147.5.910