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Phase II evaluation of 1-(2-chloroethyl)-3-(2,6-dioxo-(piperidyl)-1 nitrosourea (PCNU)(NSC-95466) in patients with advanced carcinoma of the lung.

Authors :
Ratanatharathorn V
Samson MK
Haas CD
Cummings GD
O'Connor EJ
Baker LH
Source :
American journal of clinical oncology [Am J Clin Oncol] 1983 Feb; Vol. 6 (1), pp. 99-102.
Publication Year :
1983

Abstract

Sixty-one assessable patients with advanced small cell and non-small cell carcinoma of the lung were given PCNU on an intermittent every 6-week schedule. Starting doses ranged from 75 mg/m2 for poor-risk patients to 100 mg/m2 for good-risk patients, depending on the bone marrow, liver, and renal status. Six partial responses (two small cell carcinoma, two adenocarcinoma, two large cell carcinoma) of short duration were documented. The major toxic effects were thrombocytopenia (35%) and leukopenia (16%). PCNU does not appear to have sufficient antitumor activity to warrant further investigation in advanced lung cancer.

Details

Language :
English
ISSN :
0277-3732
Volume :
6
Issue :
1
Database :
MEDLINE
Journal :
American journal of clinical oncology
Publication Type :
Academic Journal
Accession number :
6837509