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Acute clinical malaria (Plasmodium inui) in a cynomolgus monkey (Macaca fascicularis).
- Source :
-
Laboratory animal science [Lab Anim Sci] 1983 Feb; Vol. 33 (1), pp. 81-5. - Publication Year :
- 1983
-
Abstract
- Acute clinical malaria caused by Plasmodium inui was diagnosed in an adult female cynomolgus monkey (Macaca fascicularis) 4 years after importation into the United States. Stress and immunosuppression associated with experimentation completed 2 weeks earlier may have contributed to the development of severe clinical disease. Clinical findings included severe regenerative anemia, hepatosplenomegaly, weakness, lethargy, weight loss, and anorexia. The infection was treated and successfully eliminated with chloroquine hydrochloride administered intramuscularly at a dose of 5 mg/kg base given at 0, 6, 24, 48, and 72 hours. Treatment also included a blood transfusion and intensive supportive care.
- Subjects :
- Acute Disease
Animals
Antimalarials therapeutic use
Chloroquine therapeutic use
Disease Susceptibility
Female
Immunosuppression Therapy veterinary
Malaria diagnosis
Malaria drug therapy
Malaria etiology
Monkey Diseases diagnosis
Monkey Diseases drug therapy
Pneumococcal Infections complications
Pneumococcal Infections veterinary
Stress, Physiological complications
Stress, Physiological veterinary
Animal Population Groups
Animals, Wild
Macaca
Macaca fascicularis
Malaria veterinary
Monkey Diseases etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0023-6764
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Laboratory animal science
- Publication Type :
- Academic Journal
- Accession number :
- 6834780