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Assessment of left ventricular dysfunction by thallium-201 lung uptake during exercise in coronary artery disease.
- Source :
-
Japanese circulation journal [Jpn Circ J] 1983 Apr; Vol. 47 (4), pp. 381-90. - Publication Year :
- 1983
-
Abstract
- To determine the clinical significance of an increased thallium-201 (Tl-201) activity in the lung and of its clearance from the lung after exercise, computer-quantitated Tl-201 lung activity was measured and compared with hemodynamic parameters at rest and during exercise in 35 patients with coronary artery disease (CAD). All patients underwent a supine bicycle ergometer exercise test and mean pulmonary artery wedge pressure (PAWP) was measured by a Swan-Ganz catheter. Coronary angiography was also performed. On computer-generated initial and 2 and a half hours delayed anterior images, regions of interest were selected over the myocardium (M) and lung (L), and the initial L/M ratio and the (initial L)/(delayed L) ratio were calculated as indices of an increased Tl-201 lung uptake and lung clearance, respectively. The initial L/M ratio and the (initial L)/(delayed L) ratio had no significant correlation with mean PAWP at rest and had a weak negative correlation with the resting ejection fraction (r = -0.57 and r = -0.58, respectively). However, both ratios showed good correlations with mean PAWP during peak exercise (r = 0.85 and r = 0.80, respectively), suggesting that they provide useful indices for assessing the severity of exercise-induced left ventricular dysfunction.
Details
- Language :
- English
- ISSN :
- 0047-1828
- Volume :
- 47
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Japanese circulation journal
- Publication Type :
- Academic Journal
- Accession number :
- 6834644
- Full Text :
- https://doi.org/10.1253/jcj.47.381