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The inhibition of PGI2 synthetase within the arterial wall by 15-hydroperoxyarachidonic acid enhances local white platelet thrombosis.
- Source :
-
Haemostasis [Haemostasis] 1980; Vol. 9 (6), pp. 345-51. - Publication Year :
- 1980
-
Abstract
- Prostaglandins play an important role in platelet-vessel wall interaction. The inhibition of PGI2 synthetase by 15-hydroxyarachidonic acid (15-HPAA) results in an enhancement of local thrombus formation.
- Subjects :
- Animals
In Vitro Techniques
Male
Platelet Aggregation drug effects
Rats
Arachidonic Acids pharmacology
Arteries enzymology
Blood Platelets drug effects
Cyclooxygenase Inhibitors
Epoprostenol biosynthesis
Leukotrienes
Lipid Peroxides
Peroxides pharmacology
Prostaglandins biosynthesis
Thrombosis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0301-0147
- Volume :
- 9
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Haemostasis
- Publication Type :
- Academic Journal
- Accession number :
- 6778799
- Full Text :
- https://doi.org/10.1159/000214376