Back to Search
Start Over
Single-agent chemotherapy for recurrent carcinoma of the cervix.
- Source :
-
Cancer clinical trials [Cancer Clin Trials] 1980; Vol. 3 (4), pp. 345-50. - Publication Year :
- 1980
-
Abstract
- A randomized study of 59 patients with recurrent squamous carcinoma of the cervix originally treated with radiotherapy is reported. Patients were randomized on recurrence to either Hexamethylmelamine, Adriamycin, or Cytoxan as first agent. When analysis was restricted to 37 patients with easily evaluable disease, Cytoxan had a significantly greater response rate (23.1%, 3/13) than Hexamethylmelamine (0%, 0/14) (p = 0.098). The response rate of Adriamycin was 20% (2/10). There was no evidence of a significant effect of first agent on survival time taken from the start of chemotherapy. The number of months from diagnosis to the start of chemotherapy (p = 0.04) and the patients' response status (p = 0.002) did however have significant effects on survival time. There was no evidence of a significant effect of first agent on survival time after treatment change but response to first agent did have a significant effect on survival (p = 0.05). Hexamethylmelamine had a greater frequency of severe toxicity (50%, 10/20) than Adriamycin (10.5%, 2/19) (p = 0.014) and Cytoxan (10%, 2/10) (p = 0.014).
- Subjects :
- Altretamine adverse effects
Altretamine therapeutic use
Anemia chemically induced
Cyclophosphamide therapeutic use
Doxorubicin therapeutic use
Female
Humans
Nausea chemically induced
Prognosis
Vomiting chemically induced
Antineoplastic Agents therapeutic use
Carcinoma, Squamous Cell drug therapy
Neoplasm Recurrence, Local drug therapy
Uterine Cervical Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0190-1206
- Volume :
- 3
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer clinical trials
- Publication Type :
- Academic Journal
- Accession number :
- 6775827