Back to Search
Start Over
Neuroendocrine control of gonadotropin secretion.
- Source :
-
Federation proceedings [Fed Proc] 1980 Sep; Vol. 39 (11), pp. 2896-901. - Publication Year :
- 1980
-
Abstract
- Luteinizing hormone releasing hormone (LHRH), a hypothalmic peptide that is concentrated in granules of neurons, has the capacity to release gonadotropins (luteinizing hormone (LH) and follicle stimulating hormone) from the pituitary gland. LHRH has been found in hypophysial portal blood of rats, monkeys, and rabbits. Antibodies to LHRH depress plasma LH concentrations in castrated animals and evoke testicular atrophy, but passive immunization against LHRH does not block the LH surge induced by estrogen in monkeys. Estrogens, progestin, prolactin, and dopamine have marked effects on LH secretion, yet an association between these effects and altered hypophysial portal blood concentrations of LHRH is not established. In view of the paucity of evidence demonstrating such a cause and effect relationship, two alternative proposals have become tenable. One, hormones and neurotransmitters may not alter the levels of portal blood LHRH, but rather alter the frequency of pulsatile LHRH secretion. Two, hormones, such as estrogens, progesterone, and prolactin, may alter the responsiveness of the gonadotropin-secreting cells to LHRH by affecting the secretion of dopamine.
- Subjects :
- Adult
Animals
Bromocriptine
Castration
Female
Gonadotropin-Releasing Hormone immunology
Humans
Immunity, Maternally-Acquired
Male
Prolactin metabolism
Rabbits
Rats
Follicle Stimulating Hormone metabolism
Gonadotropin-Releasing Hormone physiology
Hypothalamus physiology
Luteinizing Hormone metabolism
Neurons physiology
Pituitary Gland metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-9446
- Volume :
- 39
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Federation proceedings
- Publication Type :
- Academic Journal
- Accession number :
- 6773815