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Comparison of once and twice daily administration of acebutolol in hypertension.
- Source :
-
British journal of clinical pharmacology [Br J Clin Pharmacol] 1980 Feb; Vol. 9 (2), pp. 209-12. - Publication Year :
- 1980
-
Abstract
- 1 Thirteen hypertensive patients completed a double-blind comparison of placebo, acebutolol 200 mg twice daily and acebutolol 400 mg once daily, administered for 4 weeks in random order. 2 Blood pressure and heart rate were significantly reduced by both acebutolol treatments. The mean reduction of resting pressure 12 h after 200 mg twice daily (12/7 mmHg) was similar to that 24 hr after 400 mg once daily (13/9 mmHg). 3 Compared to placebo, reductions in exercise heart rate and systolic pressure at 12 h after 200 mg twice daily and 24 h after 400 mg once daily were significant and similar. 4 Beta-adrenoceptor antagonism was also assessed by inhibition of the heart rate response to sublingual glyceryl trinitrate taken in the standing position. Both acebutolol treatments reduced the response; the reduction after twice daily treatment (mean 25 beats/min) was significantly greater than after once daily treatment (mean 19 beats/min). 5 There was no difference in blood pressure control between acebutolol administered once and twice daily in a total daily dose of 400 mg.
- Subjects :
- Acebutolol blood
Acebutolol therapeutic use
Adult
Blood Pressure drug effects
Double-Blind Method
Drug Administration Schedule
Female
Heart Rate drug effects
Humans
Hypertension physiopathology
Male
Middle Aged
Nitroglycerin
Patient Compliance
Acebutolol administration & dosage
Hypertension drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0306-5251
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- British journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6766731
- Full Text :
- https://doi.org/10.1111/j.1365-2125.1980.tb05835.x