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A leftward deletional alpha+ thalassemia found in East Sicily in conjunction with heterozygous beta-thalassemia.
- Source :
-
Human genetics [Hum Genet] 1984; Vol. 67 (2), pp. 216-8. - Publication Year :
- 1984
-
Abstract
- Two types of alpha+ thalassemia (-alpha l) have been described, respectively termed leftward and rightward, which correspond to nonhomologous crossing-over in different homology zones X and Z within the alpha-globin gene cluster. Up to now the leftward type has been described only in Asiatic populations, whereas the rightward type is universally distributed. We report here a first case of leftward deletion observed in a Sicilian male. This raises the question of an identical or not crossing-over event.
Details
- Language :
- English
- ISSN :
- 0340-6717
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Human genetics
- Publication Type :
- Academic Journal
- Accession number :
- 6745942
- Full Text :
- https://doi.org/10.1007/BF00273005