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Translocation 1;7 in dyshematopoiesis: possibly induced with a nonrandom geographic distribution.
- Source :
-
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 1984 Aug; Vol. 12 (4), pp. 283-94. - Publication Year :
- 1984
-
Abstract
- Eight patients with various hematologic disorders had an identical chromosomal aberration in their bone marrow or unstimulated peripheral blood, a translocation t(1;7) interpreted as t(1;7)(p11;p11). The translocation chromosome replaced one normal chromosome #7; therefore, the karyotype of the abnormal cells was trisomic for 1q and monosomic for 7q. Including four cases from the literature, a total of 12 patients (4 women, 8 men) with this translocation are known at the moment. The translocation does not seem to be associated with a specific disorder, but almost all patients had a preleukemic syndrome during some stage of their disease. It is very remarkable that 11 of the 12 patients lived in the Netherlands, and 7 patients had a history of iatrogenic exposure to alkylating agents or irradiation; one patient was a radiation worker and another one had a history of toxic exposure to chloramphenicol. It is suggested, therefore, that the t(1;7) is a possibly induced chromosomal aberration with a clearly nonrandom geographic distribution.
- Subjects :
- Adult
Aged
Alkylating Agents adverse effects
Female
Hematologic Diseases epidemiology
Hematologic Diseases etiology
Humans
Leukemia genetics
Male
Middle Aged
Netherlands
Ovarian Neoplasms genetics
Polycythemia genetics
Preleukemia genetics
Radiation Injuries complications
Trisomy
Chromosomes, Human, 1-3
Chromosomes, Human, 6-12 and X
Hematologic Diseases genetics
Translocation, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0165-4608
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer genetics and cytogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 6744224
- Full Text :
- https://doi.org/10.1016/0165-4608(84)90061-x