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Augmentation of dexamethasone induction of rat liver metallothionein by zinc.
- Source :
-
The Biochemical journal [Biochem J] 1984 May 01; Vol. 219 (3), pp. 959-63. - Publication Year :
- 1984
-
Abstract
- The induction of liver metallothionein by dexamethasone in adrenalectomized rats was augmented by zinc administration. Metallothionein synthesis was increased in an additive manner with both zinc and dexamethasone compared with either treatment alone. Translational activity of polyribosomal metallothionein mRNA was also greater in zinc + dexamethasone-treated rats. Northern-blot analyses showed that dexamethasone increased these mRNA contents to a greater extent at the lower zinc dose, suggesting that the induction may be maximal at the higher zinc dose when combined with dexamethasone.
Details
- Language :
- English
- ISSN :
- 0264-6021
- Volume :
- 219
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Biochemical journal
- Publication Type :
- Academic Journal
- Accession number :
- 6743254
- Full Text :
- https://doi.org/10.1042/bj2190959