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Early cellular responses in the peritoneal cavity of mice to antitumor immunomodulators.
- Source :
-
Gan [Gan] 1984 Apr; Vol. 75 (4), pp. 370-8. - Publication Year :
- 1984
-
Abstract
- The early cellular responses to antitumor immunomodulators and conventional inducers, especially the polymorphonuclear leukocyte (PMN) responses, were examined in the peritoneal cavity of mice to investigate their effect on primary defense mechanisms. Immunomodulators were classified into 5 groups in terms of PMN response on the basis of its duration (declining or persistent) and extent (high or low induction): 1) TAK (beta-1,3-glucan)-type (high, persistent), 2) lentinan-type (high, declining), 3) yeast mannan-type (low, declining), 4) LPS (lipopolysaccharide)-type (low, persistent), 5) others (no effect). Since the general PMN response is of the declining type, the persistence of PMN with TAK- and LPS-type immunomodulators is a characteristic of the PMN-inducing activity. With respect to the extent, TAK- and lentinan-type immunomodulators induced larger numbers of PMN and macrophages than conventional inducers. These results suggest that some types of immunomodulators have effects on the early host-defense mechanism. From the viewpoint of the general self-defense mechanism we also compared these PMN responses with those to bacteria and to tumor inoculation, and the properties of substances inducing high PMN response, i.e., those with the quality of "foreignness," are discussed.
- Subjects :
- Acetylmuramyl-Alanyl-Isoglutamine immunology
Actinomyces
Animals
BCG Vaccine immunology
Concanavalin A
Glucans immunology
Immunity, Cellular
Liver Neoplasms, Experimental immunology
Liver Neoplasms, Experimental pathology
Macrophages immunology
Male
Mammary Neoplasms, Experimental immunology
Mammary Neoplasms, Experimental pathology
Mice
Mice, Inbred C3H
Neoplasms, Experimental pathology
Peritoneal Cavity immunology
Picibanil immunology
Polysaccharides, Bacterial immunology
Adjuvants, Immunologic immunology
Neoplasms, Experimental immunology
Neutrophils immunology
beta-Glucans
Subjects
Details
- Language :
- English
- ISSN :
- 0016-450X
- Volume :
- 75
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Gan
- Publication Type :
- Academic Journal
- Accession number :
- 6735035