A simple method of determining 4-hydroxyisovaleric acid and its level in a patient with isovaleric acidemia.

Authors :: Shigematsu Y
Kikawa Y
Sudo M
Kikuchi K
Ohta S
Okamoto M
Source :: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 1984 Apr 27; Vol. 138 (3), pp. 333-6.
Publication Year :: 1984
Abstract: We developed a simple and rapid method for the quantitative determination of 4- hydroxyisovaleric acid using the conversion of this acid to the corresponding lactone,and measured its levels in the plasma of a patient with isovaleric acidemia during an episode of severe ketoacidosis. 4-Hydroxyisovaleric acid reached a peak two days after plasma isovaleric acid was at its highest level.

Subjects :: Gas Chromatography-Mass Spectrometry
Hemiterpenes
Humans
Ketosis urine
Valerates urine
Acidosis blood
Ketosis blood
Pentanoic Acids blood
Valerates blood

Language :: English
ISSN :: 0009-8981
Volume :: 138
Issue :: 3
Database :: MEDLINE
Journal :: Clinica chimica acta; international journal of clinical chemistry
Publication Type :: Academic Journal
Accession number :: 6723068
Full Text :: https://doi.org/10.1016/0009-8981(84)90141-4

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