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[Use of liposomes as a nonspecific detoxifier in the crush syndrome].

Authors :
Stefanov AV
Kreĭnes VM
Dmitrieva AV
Lishko VK
Source :
Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1984 May; Vol. 97 (5), pp. 569-72.
Publication Year :
1984

Abstract

The possibility of parenteral detoxification was studied in dogs with the experimental crush syndrome. Infusion of lecithin liposomes (25 and 50 mg/kg) prevented the development of postcompression toxemia and hemodynamic disorders characteristic for endogenous intoxication. The use of the nonspecific parenteral sorbent lecithin liposomes permitted the maintenance of an adequate function of the animals' cardiovascular system for 5 hours after decompression.

Details

Language :
Russian
ISSN :
0365-9615
Volume :
97
Issue :
5
Database :
MEDLINE
Journal :
Biulleten' eksperimental'noi biologii i meditsiny
Publication Type :
Academic Journal
Accession number :
6722333