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The role of apoptosis in atrophy of the small gut mucosa produced by repeated administration of cytosine arabinoside.
- Source :
-
The Journal of pathology [J Pathol] 1984 Apr; Vol. 142 (4), pp. 259-63. - Publication Year :
- 1984
-
Abstract
- Progressive atrophy of ileal crypts and villi following daily administration of cytosine arabinoside to mice was found to be the result of suppression of mitosis and marked enhancement of apoptosis in the crypt epithelium. The amount of apoptosis produced by each dose decreased as the atrophy advanced. Mucosal regeneration after cessation of administration of the drug was due to increased mitosis in the crypts, and was associated with complete restoration of susceptibility of the crypt cells to further doses. During early regeneration, the wave of increased mitosis was accompanied by a wave of mildly increased apoptosis.
- Subjects :
- Animals
Atrophy chemically induced
Atrophy pathology
Cell Survival drug effects
Ileum drug effects
Ileum physiology
Intestinal Mucosa drug effects
Intestinal Mucosa physiology
Male
Mice
Microscopy, Electron
Mitosis drug effects
Regeneration drug effects
Time Factors
Cytarabine toxicity
Ileum ultrastructure
Intestinal Mucosa ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3417
- Volume :
- 142
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 6716211
- Full Text :
- https://doi.org/10.1002/path.1711420404