Back to Search Start Over

[Alkyl and aryl derivatives of isoquinoline. II. Synthesis and pharmacologic activity of dialkylaminoalkyl esters of 1-chloro-3-carboxy-4-methylisoquinoline and the corresponding 4-phenyl derivative].

Authors :
Vittorio F
Santagati NA
Lancetta T
Duro F
Arrigo Reina R
Cosentino C
Source :
Il Farmaco; edizione scientifica [Farmaco Sci] 1984 Mar; Vol. 39 (3), pp. 217-28.
Publication Year :
1984

Abstract

The synthesis of a series of dialkylaminoalkylic esters of 1-chloro-3-carboxy-4-methylisoquinoline and of 1-chloro-3-carboxy-4-phenylisoquinoline is described. The pharmacological activity of some of these compounds was studied. The morpholinoethylester of 1-chloro-3-carboxy-4-methylisoquinoline (VIIa), dimethylaminoethylester (VIIb) and diethylaminoethylester (VIIc) showed a good antispasmodic activity. 4-Phenyl-derivatives (XVa), (XVb), (XVc) were more active than analogous 4-methyl derivatives; particularly the diethylaminoethylester of 1-chloro-3-carboxy-4-phenylisoquinoline (XVc) showed an antagonist effect against spasmogens similar to that of papaverine.

Details

Language :
Italian
ISSN :
0430-0920
Volume :
39
Issue :
3
Database :
MEDLINE
Journal :
Il Farmaco; edizione scientifica
Publication Type :
Academic Journal
Accession number :
6714415