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[Alkyl and aryl derivatives of isoquinoline. II. Synthesis and pharmacologic activity of dialkylaminoalkyl esters of 1-chloro-3-carboxy-4-methylisoquinoline and the corresponding 4-phenyl derivative].
- Source :
-
Il Farmaco; edizione scientifica [Farmaco Sci] 1984 Mar; Vol. 39 (3), pp. 217-28. - Publication Year :
- 1984
-
Abstract
- The synthesis of a series of dialkylaminoalkylic esters of 1-chloro-3-carboxy-4-methylisoquinoline and of 1-chloro-3-carboxy-4-phenylisoquinoline is described. The pharmacological activity of some of these compounds was studied. The morpholinoethylester of 1-chloro-3-carboxy-4-methylisoquinoline (VIIa), dimethylaminoethylester (VIIb) and diethylaminoethylester (VIIc) showed a good antispasmodic activity. 4-Phenyl-derivatives (XVa), (XVb), (XVc) were more active than analogous 4-methyl derivatives; particularly the diethylaminoethylester of 1-chloro-3-carboxy-4-phenylisoquinoline (XVc) showed an antagonist effect against spasmogens similar to that of papaverine.
- Subjects :
- Acetylcholine antagonists & inhibitors
Analgesics chemical synthesis
Animals
Anti-Inflammatory Agents chemical synthesis
Barium antagonists & inhibitors
Central Nervous System drug effects
Chemical Phenomena
Chemistry
Guinea Pigs
Histamine Antagonists chemical synthesis
In Vitro Techniques
Isoquinolines pharmacology
Male
Mice
Motor Activity drug effects
Rats
Rats, Inbred Strains
Isoquinolines chemical synthesis
Parasympatholytics chemical synthesis
Subjects
Details
- Language :
- Italian
- ISSN :
- 0430-0920
- Volume :
- 39
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Il Farmaco; edizione scientifica
- Publication Type :
- Academic Journal
- Accession number :
- 6714415