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Vitamin E deficiency with normal serum vitamin E concentrations in children with chronic cholestasis.
- Source :
-
The New England journal of medicine [N Engl J Med] 1984 May 10; Vol. 310 (19), pp. 1209-12. - Publication Year :
- 1984
-
Abstract
- We studied serum vitamin E levels and the ratio of serum vitamin E to serum lipid levels in 11 children with chronic cholestasis complicated by vitamin E deficiency, as defined by characteristic neurologic signs or sural-nerve histopathology in addition to impaired intestinal absorption of vitamin E. Eight of the children had low levels of serum vitamin E, as well as low ratios of serum vitamin E to total lipids and to cholesterol. However, three patients had normal serum vitamin E levels but low ratios of serum vitamin E to total lipids (two of the three had normal ratios of vitamin E to cholesterol). In four patients who were not vitamin E-deficient, all three values were normal. We conclude that vitamin E deficiency may exist in a child with a normal serum vitamin E concentration and that the ratio of serum vitamin E to total serum lipids is the most reliable biochemical index of vitamin E status during chronic childhood cholestasis.
Details
- Language :
- English
- ISSN :
- 0028-4793
- Volume :
- 310
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- The New England journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6709026
- Full Text :
- https://doi.org/10.1056/NEJM198405103101901