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Gastric secretory conditions and plasma gastrin levels in rats after prolonged treatment with cimetidine.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 1984 Jan; Vol. 29 (1), pp. 40-5. - Publication Year :
- 1984
-
Abstract
- Effects of 4 weeks of treatment with oral cimetidine, 100 mg/kg twice daily, on gastric secretion and plasma gastrin levels were studied in rats. Pylorus ligation-induced and pentagastrin-stimulated gastric secretions were little changed at days 1, 3, and 10 after cessation of cimetidine treatment as compared to the controls. Histamine-stimulated acid secretion was significantly higher in the cimetidine-treated group than in the controls at day 3 after cimetidine treatment but was unchanged at days 1 and 10. A single oral administration of cimetidine at 100 mg/kg significantly increased plasma gastrin levels 4 hr after the treatment in refed rats but not at 2 and 8 hr later. Plasma gastrin levels significantly decreased at days 3 and 10 after cessation of cimetidine treatment as compared to the controls. Thus, while prolonged treatment with cimetidine induces a transient increase in response of parietal cells to histamine and a reduction of food-stimulated gastrin release, it does not seem to induce other appreciable changes in gastric secretion.
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 6692731
- Full Text :
- https://doi.org/10.1007/BF01296860