Back to Search
Start Over
Classical conditioning, decay and extinction of cocaine-induced hyperactivity and stereotypy.
- Source :
-
Life sciences [Life Sci] 1983 Oct 03; Vol. 33 (14), pp. 1341-51. - Publication Year :
- 1983
-
Abstract
- Following 10 daily pairings of multiple conditioned stimuli with injection of cocaine (15 mg/kg), the presentation of the stimuli alone elicited behaviors in rats similar to those induced by cocaine. The behaviors included increased duration or frequency of rearing, sniffing, head bobbing, and horizontal locomotor activity (crossing). The level of the conditioned response for several of these behaviors approximated that induced by the drug itself. The conditioned drug effect showed decay over 15 days but little extinction during 4 daily trials. Brain concentrations of the dopamine metabolites, homovanillic acid and dihydroxyphenylacetic acid, were similar in the conditioned and pseudoconditioned control groups in both the caudate and mesolimbic areas. The behavioral results demonstrate that, in a classical conditioning paradigm, previously neutral stimuli can elicit behaviors similar to those induced by cocaine and that certain conditioned responses show time related decline. This agrees with the reported conditioning of amphetamine's behavioral effects but differs in terms of the action on brain dopamine turnover.
- Subjects :
- 3,4-Dihydroxyphenylacetic Acid analysis
Animals
Brain drug effects
Brain metabolism
Brain Chemistry
Dopamine metabolism
Homovanillic Acid analysis
Humans
Male
Rats
Rats, Inbred Strains
Time Factors
Cocaine pharmacology
Conditioning, Classical drug effects
Extinction, Psychological drug effects
Hyperkinesis drug effects
Stereotyped Behavior drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0024-3205
- Volume :
- 33
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 6684721
- Full Text :
- https://doi.org/10.1016/0024-3205(83)90817-2