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Chlorpromazine-induced neuroleptic malignant syndrome and its response to diazepam.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1983 Dec; Vol. 18 (12), pp. 1441-6. - Publication Year :
- 1983
-
Abstract
- We have observed two cases of chlorpromazine-induced neuroleptic malignant syndrome (NMS); both were transiently responsive to intravenous diazepam challenge, but not to blind placebo or amyobarbitol. The interrelationship, via feedback between central dopaminergic and gamma-aminobutyric (GABA) systems is reviewed. A theoretical role for a relative DA-GABA imbalance during NMS and treatment implications are discussed.
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 18
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 6661471