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A specific orally active inhibitor of angiotensin-converting enzyme in man.
- Source :
-
Lancet (London, England) [Lancet] 1977 Apr 09; Vol. 1 (8015), pp. 775-8. - Publication Year :
- 1977
-
Abstract
- An orally active inhibitor of the angiotensin-converting enzyme, SQ 14,225 (D-2-methyl-3-mercaptopropanoly-L-proline), was administered to fourteen normal male volunteers to evaluate its safety and efficacy in inhibiting pressor responses to exogenous angiotensin I. SQ 14,225 produced significant blockade within 15 min of oral administration. The magnitude and duration of inhibition were dose-related. After a dose of 20 mg, complete blockade was observed for more than 2 h and partial inhibition for over 4 h. There was no effect on pressor responses to angiotensin II. SQ 14,225 promises to provide a new approach to the diagnosis and treatment of disorders involving over-activity of the renin-angiotensin system.
- Subjects :
- Administration, Oral
Adult
Angiotensin II administration & dosage
Angiotensin II pharmacology
Blood Pressure drug effects
Dose-Response Relationship, Drug
Drug Antagonism
Humans
Injections, Intravenous
Male
Proline administration & dosage
Proline pharmacology
Renin blood
Sulfhydryl Compounds administration & dosage
Sulfhydryl Compounds pharmacology
Time Factors
Angiotensin-Converting Enzyme Inhibitors
Proline analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0140-6736
- Volume :
- 1
- Issue :
- 8015
- Database :
- MEDLINE
- Journal :
- Lancet (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 66571
- Full Text :
- https://doi.org/10.1016/s0140-6736(77)92958-0