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Genetic effects of radiocarbon in reproductive cells of male mice.
- Source :
-
Mutation research [Mutat Res] 1983 Dec; Vol. 122 (3-4), pp. 341-6. - Publication Year :
- 1983
-
Abstract
- The genetic effect of incorporated radiocarbon was studied after single, long-term (33 days) and chronic (6 and 12 months) treatment of male mice (CBA X C57B1) F1 with [14C]glucose. The genetic effect in male germ cells was estimated by 3 tests: DLM frequency in post- and pre-meiotic cells, RT frequency in stem spermatogonia and frequency of abnormal sperm heads. Absorbed doses in the gonads were: 0.22, 0.50 and 1.01 Gy, after a single exposure; 0.74 and 1.47 Gy, after long-term exposures; and 0.006 and 0.031 Gy, after chronic exposure for 6 months; and 0.013 and 0.066 Gy, for 12 months. The results suggest that DLM frequency in post-meiotic cells increased linearly with increasing the dose of 14C single and long-term exposures at a dose of 1.47 Gy only. A chronic treatment with [14C]glucose induced no increase in DLM frequency. RT frequency in stem spermatogonia was statistically significantly higher than the control level after the single and long-term exposure to 14C. A comparison of the results with the results of external single and chronic gamma-irradiation allows the conclusion that the relative genetic efficiency of radiocarbon as compared with that of gamma-rays is about 1.
- Subjects :
- Animals
Dose-Response Relationship, Radiation
Drug Administration Schedule
Glucose administration & dosage
Male
Mice
Mice, Inbred Strains
Translocation, Genetic
Carbon Radioisotopes adverse effects
Genes, Dominant radiation effects
Genes, Lethal radiation effects
Mutation
Reproduction radiation effects
Spermatogonia radiation effects
Spermatozoa radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 0027-5107
- Volume :
- 122
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Mutation research
- Publication Type :
- Academic Journal
- Accession number :
- 6656816
- Full Text :
- https://doi.org/10.1016/0165-7992(83)90017-9