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Ultrastructural study of peripheral nerve in arteritic diabetic patients.
- Source :
-
Acta neuropathologica [Acta Neuropathol] 1983; Vol. 61 (3-4), pp. 225-31. - Publication Year :
- 1983
-
Abstract
- The peripheral nerve was taken from 25 diabetic patients with arteritis just before or after amputation of a leg. The ultrastructural study of myelinated fibers showed several alterations. Loss of fibers varied greatly from case to case. This was accompanied in some cases by hypertrophy of the Schwann cells around demyelinated fibers as has been observed in some ordinary diabetic neuropathies. Unusual abnormalities consisted of particular axonal degeneration and evidence of aberrant remyelination. This axonal injury was peculiar because of the accumulation of organelles which tended to transform some of the fibers into enlarged axons. Such a lesion might correspond to a hypoxic axonopathy.
- Subjects :
- Aged
Arteritis complications
Axons ultrastructure
Diabetes Complications
Female
Humans
Hypertrophy
Hypoxia complications
Male
Microscopy, Electron
Middle Aged
Nerve Fibers, Myelinated ultrastructure
Schwann Cells ultrastructure
Arteritis pathology
Diabetic Neuropathies pathology
Peripheral Nerves ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 0001-6322
- Volume :
- 61
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Acta neuropathologica
- Publication Type :
- Academic Journal
- Accession number :
- 6650135
- Full Text :
- https://doi.org/10.1007/BF00691990