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5-Fluorouracil, vincristine and hydroxyurea combination chemotherapy in metastatic colorectal cancer.
- Source :
-
Tumori [Tumori] 1983 Oct 31; Vol. 69 (5), pp. 485-7. - Publication Year :
- 1983
-
Abstract
- Twenty consecutive patients who had biopsy proven metastatic colorectal cancer were treated with combination chemotherapy. The drug regimen (FVH), in a 4 week cycle, consisted of 5-fluorouracil (600 mg/m2 i.v. on days 1, 8, 15 and 22), vincristine (1.4 mg/m2 i.v. on day 4), and hydroxyurea (2400 mg/m2 p.o. on days 3, 10, 17 and 24). Three of the 18 evaluable patients achieved an objective tumor remission (2 CR and 1 PR) and 15 patients had stable disease. The overall response rate to FVH was therefore not superior to that achieved in patients who received 5-fluorouracil alone, and the overall survival in this study was comparable to that of other studies involving patients with metastatic colorectal cancer.
- Subjects :
- Colonic Neoplasms mortality
Female
Fluorouracil therapeutic use
Humans
Hydroxyurea administration & dosage
Male
Middle Aged
Neoplasm Metastasis
Rectal Neoplasms mortality
Vincristine administration & dosage
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Colonic Neoplasms drug therapy
Rectal Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0300-8916
- Volume :
- 69
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Tumori
- Publication Type :
- Academic Journal
- Accession number :
- 6649073
- Full Text :
- https://doi.org/10.1177/030089168306900519