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Allergenic properties of naturally occurring cannabinoids.
- Source :
-
Journal of pharmaceutical sciences [J Pharm Sci] 1983 Aug; Vol. 72 (8), pp. 954-5. - Publication Year :
- 1983
-
Abstract
- The guinea pig maximization test was used to determine the potential of seven cannabinoids to produce allergic contact dermatitis. delta 9-Tetrahydrocannabinol and cannabinol were found to be extreme (Grade V) sensitizers. Cannabidiol, delta 8-tetrahydrocannabinol, and cannabichromene were moderate (Grade III) sensitizers. Cannabigerol and cannabinol methyl ether were not sensitizers. Most of the cannabinoids were found to be allergenically cross-reactive. Additionally, it was shown that the presence of a free 1'-hydroxyl group was required for sensitization, but not to elicit a response in sensitive animals.
- Subjects :
- Animals
Cross Reactions
Female
Guinea Pigs
Allergens
Cannabinoids immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3549
- Volume :
- 72
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of pharmaceutical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 6620158
- Full Text :
- https://doi.org/10.1002/jps.2600720831