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The synthesis, bioactivity and enzyme stability of D-Ala2, EPhe4, Leu5-enkephalins.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1983 Aug 30; Vol. 115 (1), pp. 112-5. - Publication Year :
- 1983
-
Abstract
- We have synthesized the first enkephalin analog containing a "cyclopropyl" phenylalanine (Phe) residue. The E-configuration of this residue is apparently responsible for its low activity in the MVD and GPI muscle assays. The enkephalin is very stable to cleavage by carboxypeptidase Y.
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 115
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 6615520
- Full Text :
- https://doi.org/10.1016/0006-291x(83)90976-2