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Adenosine reduces catecholamine contractile responses in oxygenated and hypoxic atria.
- Source :
-
The American journal of physiology [Am J Physiol] 1983 Sep; Vol. 245 (3), pp. H468-74. - Publication Year :
- 1983
-
Abstract
- The properties of adenosine attenuation of catecholamine-elicited increases in peak contractile force, rate of force development, and rate of relaxation were studied in isolated rat atria. Adenosine, at a concentration that did not cause a direct depressant effect by itself, was capable of reducing by approximately 15% the increase in the contractile parameters elicited by isoproterenol. This reduction was not overcome by elevating the catecholamine concentration. The adenosine reduction was prevented by theophylline or the presence of adenosine deaminase. The reduction appears to be independent of the acetylcholine-mediated reduction of catecholamine responses. Adenosine reduced the positive inotropic responses elicited by norepinephrine and epinephrine but not phenylephrine. Adenosine deaminase in oxygenated atria potentiated the catecholamine-elicited contractile responses and reduced the progressive fall of the elevated contractile responses observed with continual catecholamine stimulation. In hypoxic atria adenosine deaminase potentiated the positive inotropic responses observed with catecholamine stimulation. The results suggest that an adenosine-specific mechanism is capable of attenuating the elevation in contractility elicited by beta-adrenergic stimulation. In addition, endogenous adenosine may be responsible, in part, for the reduction of catecholamine-mediated contractile responses in oxygenated and hypoxic myocardial tissue.
- Subjects :
- Acetylcholine pharmacology
Adenosine Deaminase metabolism
Animals
Atrial Function
Atropine pharmacology
Heart Atria drug effects
Isoproterenol pharmacology
Male
Rats
Rats, Inbred Strains
Theophylline pharmacology
Adenosine pharmacology
Epinephrine pharmacology
Myocardial Contraction drug effects
Norepinephrine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9513
- Volume :
- 245
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 6614194
- Full Text :
- https://doi.org/10.1152/ajpheart.1983.245.3.H468