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Moxalactam retinal toxicity.
- Source :
-
Archives of ophthalmology (Chicago, Ill. : 1960) [Arch Ophthalmol] 1984 Mar; Vol. 102 (3), pp. 435-8. - Publication Year :
- 1984
-
Abstract
- Moxalactam disodium is a new third-generation semisynthetic, broad-spectrum, cephalosporin-like antibiotic for parenteral administration. Topical, subconjunctival, and intravenous administration provide poor concentration in the vitreous. To determine its toxicity in intravitreal administration, we injected comparative doses directly into the vitreous cavity of 21 rabbits. With doses of 1.25 mg or less there was no toxic damage to the retina. With a dose of 2.5 mg, early degeneration of photoreceptors was seen after three months. With higher doses (5 and 10 mg) there were major histopathologic and electroretinographic changes. These results suggest the feasibility of employing moxalactam in the treatment of acute, severe, fulminant bacterial endophthalmitis.
- Subjects :
- Animals
Bacterial Infections pathology
Electroretinography
Endophthalmitis pathology
Injections
Microscopy, Electron
Mitochondrial Swelling drug effects
Moxalactam administration & dosage
Photoreceptor Cells drug effects
Photoreceptor Cells ultrastructure
Rabbits
Rod Cell Outer Segment drug effects
Rod Cell Outer Segment ultrastructure
Vitreous Body
Moxalactam toxicity
Retina drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9950
- Volume :
- 102
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of ophthalmology (Chicago, Ill. : 1960)
- Publication Type :
- Academic Journal
- Accession number :
- 6608344
- Full Text :
- https://doi.org/10.1001/archopht.1984.01040030349036