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A fibrin adhesive seal for the repair of osteochondral fracture fragments.
- Source :
-
Clinical orthopaedics and related research [Clin Orthop Relat Res] 1984 Jan-Feb (182), pp. 258-63. - Publication Year :
- 1984
-
Abstract
- A biologic tissue adhesive, a two-component fibrin sealant, for the immobilization of experimentally produced osteochondral fractures of the radial head and femoral condyle was investigated in dogs. The two components of the fibrin sealant were a sealer protein solution (fibrinogen) and a thrombin solution. A fibrinolytic inhibitor (C-esterase inhibitor) was added to prevent degradation of the fibrin by proteolytic enzymes. The operation was performed in 16 joints in four dogs. Control fractures on the right side were fixed with 5-cm Kirschner wires. No external immobilization was utilized. The dogs were killed at intervals of two, four, and eight weeks. There were no complications. All fractures healed uneventfully by eight weeks. Osseous repair seemed to be stimulated by the sealant and to occur faster than in the fractures fixed with pins.
- Subjects :
- Animals
Dogs
Drug Combinations therapeutic use
Femoral Fractures physiopathology
Fibrin Tissue Adhesive
Fracture Fixation, Internal
Osteogenesis
Radius Fractures physiopathology
Wound Healing
Factor XIII therapeutic use
Femoral Fractures therapy
Fibrinogen therapeutic use
Radius Fractures therapy
Thrombin therapeutic use
Tissue Adhesives therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0009-921X
- Issue :
- 182
- Database :
- MEDLINE
- Journal :
- Clinical orthopaedics and related research
- Publication Type :
- Academic Journal
- Accession number :
- 6607148