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Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS).
- Source :
-
Science (New York, N.Y.) [Science] 1983 May 20; Vol. 220 (4599), pp. 865-7. - Publication Year :
- 1983
-
Abstract
- Several isolates of a human type-C retrovirus belonging to one group, known as human T-cell leukemia virus (HTLV), have previously been obtained from patients with adult T-cell leukemia or lymphoma. The T-cell tropism of HTLV and its prevalence in the Caribbean basin prompted a search for it in patients with the epidemic T-cell immune deficiency disorder known as AIDS. Peripheral blood lymphocytes from one patient in the United States and two in France were cultured with T-cell growth factor (TCGF) an shown to express HTLV antigens. Virus from the U.S. patient was isolated and characterized and shown to be related to HTLV subgroup I. The virus was also transmitted into normal human T cells from umbilical cord blood of a newborn. Whether or not HTLV-I or other retroviruses of this family with T-cell tropism cause AIDS, it is possible that patients from whom the virus can be isolated can also transmit it to others. If the target cell of AIDS is the mature T cell as suspected, the methods used in these studies may prove useful for the long-term growth of these cells and for the identification of antigens specific for the etiological agent of AIDS.
- Subjects :
- Acquired Immunodeficiency Syndrome etiology
Acquired Immunodeficiency Syndrome immunology
Animals
Antibodies, Monoclonal immunology
Antibodies, Viral immunology
Female
Humans
Immunity, Cellular
Male
T-Lymphocytes microbiology
Tumor Virus Infections complications
Tumor Virus Infections transmission
Acquired Immunodeficiency Syndrome microbiology
Retroviridae isolation & purification
Tumor Virus Infections microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 220
- Issue :
- 4599
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 6601823
- Full Text :
- https://doi.org/10.1126/science.6601823