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HLA and Kaposi's sarcoma in Sardinia.
- Source :
-
Tissue antigens [Tissue Antigens] 1984 Apr; Vol. 23 (4), pp. 240-5. - Publication Year :
- 1984
-
Abstract
- Twelve Sardinian patients affected by histologically defined classic Kaposi's sarcoma (KS) were HLA-A, B, C and DR typed. Compared to 220 age and ethnically matched healthy controls, KS patients showed a significant increase in HLA-DR5 (66.6 vs 23.1%, P less than 0.001) and a considerable decrease in HLA-DR3 (8.3 vs 53.6%, P = 0.0055). No definite association was observed for other HLA antigens. These results confirm the existence of an HLA associated genetic control of KS susceptibility and support the hypothesis that HLA-DR5 plays the role of a predisposition marker while HLA-DR3 bears a genetic resistance to the disease.
Details
- Language :
- English
- ISSN :
- 0001-2815
- Volume :
- 23
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Tissue antigens
- Publication Type :
- Academic Journal
- Accession number :
- 6587615
- Full Text :
- https://doi.org/10.1111/j.1399-0039.1984.tb00038.x