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Mescaline elicits behavioral effects in cats by an action at both serotonin and dopamine receptors.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1983 Dec 09; Vol. 96 (1-2), pp. 151-4. - Publication Year :
- 1983
-
Abstract
- The characteristic behavioral effects of mescaline in cats were nearly completely blocked by pretreatment with low doses of either a specific serotonin antagonist (methysergide) or a dopamine specific antagonist (haloperidol). These blocking effects were not due to non-specific actions, since methysergide did not block the behavioral effects of apomorphine, and haloperidol did not block the behavioral effects of 5-methoxy-N,N-dimethyltryptamine. Thus, it appears that the behavioral effects of mescaline are dependent upon the simultaneous action of the drug at both serotonin and dopamine receptors.
- Subjects :
- 5-Methoxytryptamine pharmacology
Animals
Apomorphine pharmacology
Cats
Drug Interactions
Female
Male
Mescaline pharmacology
Receptors, Dopamine drug effects
Receptors, Serotonin drug effects
Behavior, Animal drug effects
Haloperidol pharmacology
Mescaline antagonists & inhibitors
Methysergide pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 96
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 6581976
- Full Text :
- https://doi.org/10.1016/0014-2999(83)90544-7