Hematoporphyrin-sensitized photodynamic inactivation of viral RNA-dependent DNA polymerase.

Authors :: Munson BR
Fiel RJ
Source :: Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1977 Jan; Vol. 16 (1), pp. 175-8.
Publication Year :: 1977
Abstract: Visible light (6328A) was shown to inactivate RNA-dependent DNA polymerase activity of Moloney mouse leukemia virus, in the presence of hematoporphyrin. The same treatment on exogenous, template-initiation complex had no effect on enzyme activity. It was suggested that this enzyme may be the target of photodynamic inactivation of this and related viruses.

Subjects :: Lasers
Moloney murine leukemia virus drug effects
Moloney murine leukemia virus radiation effects
RNA-Directed DNA Polymerase metabolism
Time Factors
Hematoporphyrins pharmacology
Light
Moloney murine leukemia virus enzymology
RNA-Directed DNA Polymerase radiation effects

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